TR&D 4

Principal Investigator: Prof. Arjun G. Yodh

Starting with seminal contributions in the late 1980s, past and present group members of the CMROI OpticalImaging Core (TR & D 4) have repeatedly made pioneering contributions to the field of diffuse optics. The group recognized early-on that near-infrared (NIR) light diffuses in tissue and that diffuse optical spectroscopy (DOS) can be used to track deep tissue hemodynamics in brain and muscle. Later, members of the group made critical theoretical and experimental contributions to problems in diffuse optical tomography (DOT) and towards the development and application of dynamical diffuse optical probes, i.e. diffuse correlation spectroscopy (DCS), whereby temporal fluctuations of diffusing light fields are used to characterize tissue blood flow, Now the group is active combining the optical methods with other modalities such as ultrasound, MRI and PET, and the group is vigorously pushing in vivo clinical applications in brain hemodynamics and metabolism, in stroke and brain injury monitoring, in muscle function monitoring, in tumor biology, in monitoring head and neck cancer treatment, and in breast tumor detection and characterization.