All human research is performed under guidelines set by University of Pennsylvania’s Institutional Review Board (IRB) with full accreditation by the Association for the Accreditation of Human Research Protection Programs. Accreditation standards establish the highest expectations for the conduct and oversight of human research. Further oversight of all MRI-based research on the clinical scanners is provided by the Center for Advanced Magnetic Resonance Imaging and Spectroscopy (CAMRIS), located within the Department of Radiology of the Hospital of the University of Pennsylvania.  It is responsible for maintenance, safety and staffing of Siemens human research MRI systems in the Department.  Maintenance includes service, upgrades and cryogen refills.  In addition to MRI technologists skilled in imaging research protocols,  an on-call Radiologist is available and the scanners are equipped with full physiological monitoring capabilities, crash carts, and are accessible to Hospital code teams.  A local Siemens engineer is available to address malfunctions. A CAMRIS committee reviews applications for MRI research studies on the Siemens systems for safety and feasibility and provides approval.

The University of Pennsylvania has a complete ALICE-approved small animal care facility.  It is maintained by a fully licensed, NIH-approved University Laboratory Animal Resource (ULAR). Facilities provided by ULAR include boarding, routine inspection for disease, treatment, surgical facilities, and assistance from veterinarians. This facility is fully accredited by AAALAC, demonstrating compliance with NIH Guidelines. The Institutional Animal Care and Use Committee (IACUC) oversees the operation of all animal facilities and approves all protocols for animal use. The Department of Radiology provides further support and oversight through its Small Animal Imaging Facility (SAIF).  In addition to the Animal Resource Center facilities, a surgery room equipped with complete surgical facilities and monitoring equipment is available with equipment such as anesthesia equipment, animal respirator and ventilator, EKG, transducers and hemodynamic monitors are available.