NMR/MRI Research Facilities
The primary instrument of the Resource is a 7 Tesla whole-body Siemens MRI scanner dedicated to 100% multi-nuclear MRI research. The system is capable of performing imaging and spectroscopy studies on a variety of NMR visible nuclei, including 1H, 31P, 13C, 23Na, 19F, 17O, 7Li, 14N, 15N, 129Xe, and 3He. The pulse-programming environment allows for development of sophisticated pulse sequences. Sequences performed at the Resource have included T1ρMRI, Sodium MRI, multiple quantum spectroscopy and imaging, MR elastography, localized spectroscopy, and perfusion imaging.
Additionally, a 1.5 Tesla Siemens Sonata and two 3 Tesla Siemens Trio clinical scanners are available in the Hospital of the University of Pennsylvania. These systems have integrated body RF coils in addition to quadrature head coils, with gradient coils capable of imaging at 40 mT / m with slew rates in excess of 200 T / m / s. Echo-planar imaging, diffusion imaging, angiography, spectroscopy, and spectroscopic imaging are standard on these systems. The center also has a 9.4 T / 20 cm bore and a 4.7 T / 12 cm horizontal bore systems and a 9.4 T / 8 cm vertical-bore system used primarily for animal and ex vivo sample imaging.
The Biomedical High Resolution NMR facility is equipped with AM500 Bruker, WH 360 Bruker and AMX 300 Bruker MR spectrometers equipped with gradient coils for high resolution imaging of mice and rats. The AMX 300 and AM500 are fiber optically linked together for fast data transfer. The facility also has a Sun Workstation for data processing. Full-time personnel are available to users of this facility.