Technology Research and Development – TR&D
The research capabilities of the CMROI are distributed into four distinct divisions called Technology Research and Development cores. The Resource emphasizes clinical translation of its TR&D work and actively collaborates and services ongoing research projects. It provides dissemination of technologies and training in their use, including a state-of-the-art whole-body 7T MRI scanner, optical imaging and hyperpolarized gas imaging systems, and software developed at the CMROI. While each TR&D is semi-autonomous in their individual research goals, extensive collaboration exists between the four groups as well as within the external scientific community.
TR&D 1 – Rotating Frame Imaging Methods
The first TR&D project deals with the development of novel rotating frame MRI techniques for studying the structural, biochemical and metabolic aspects of cartilage, brain, and tumors, with direct application to Arthritis, Alzheimer‛s Disease and cancer.
TR&D 2 – Perfusion Imaging
The second TR&D focuses on the development of quantitative perfusion MRI at ultra high field (7T) scanners, real time fMRI as well as methods for integrating perfusion MRI with optical imaging for the study of stroke and neurodegeneration.
TR&D 3 – Dynamic Radial MRI
The third TR&D develops novel image reconstruction strategies to overcome artifacts due to motion and to quantify the rapid dynamics of contrast agents in cancer and to acquire dynamic hyperpolarized gas MRI of the lungs.
TR&D 4 – Optical Imaging
The final TR&D develops multi-modal state-of-the-art instrumentation combining optical imaging and MRI, and develops diffuse correlation spectroscopy (DCS) for blood flow monitoring/imaging of diseased tissues in stroke and breast cancer.