Ravinder Reddy, Ph.D.

Subgroup: Director, Executive Committee Ravinder Reddy

Director, CMROI

Professor, Department of Radiology

Contact Information

Tel: 215-898-5708
Fax: 215-573-2113
Email: krr@upenn.edu

Education

Ph.D. 1989 Indian Institute of Technology, Kanpur (Chemistry)
M.Sc. 1982 Kakatiya University, Warangal (Chemistry)
B.Sc. 1979 Osmania University, Hyderabad (Chemistry)

Recent Work

Research Interests

My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.

Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.

Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.

Selected Publications

Selected peer-reviewed publications (from over 100)

Kogan F, Hariharan H, Reddy RChemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications. Curr Radiol Rep.2013 Jun 1 ; 1(2):102-114. PMCID: PMC23730540

Kogan F, Singh A, Debrosse C, Haris M, Cai K, Nanga RP, Elliott M, Hariharan H, Reddy RImaging of glutamate in the spinal cord using GluCEST. 2013 Aug 15;77:262-7. doi: 10.1016/j.neuroimage.2013.03.072. Epub 2013 Apr 9. PMCID: PMC23583425.

Cai K, Singh A, Roalf DR, Nanga RP, Haris M, Hariharan H, Gur R, Reddy RMapping glutamate in subcortical brain structures using high-resolution GluCEST MRI. NMR Biomed. 2013 Apr 3. doi: 10.1002/nbm.2949. PMCID: PMC23553932.

Kogan F, Haris M, Singh A, Cai K, DeBrosse C, Nanga RPR, Hariharan H, Reddy R.  Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer. Magn. Reson. Med. (2013) Feb 14. doi: 10.1002/mrm.24641. [Epub ahead of print] PMCID: PMC23412909, NIHMS435351.

Haris M, Nath K, Cai K, Singh A, Crescenzi R, Kogan F, Verma G, Reddy S, Hariharan H, Melhem ER, Reddy RImaging of glutamate neurotransmitter alterations in Alzheimer's disease.  2013 Feb 14. doi: 10.1002/mrm.24641. PMCID: PMC23412909.

Haris M, Singh A, Cai K, Nath K, Crescenzi R, Kogan F, Hariharan H, Reddy RMICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. 2013 Jan 15;212(1):87-93. doi: 10.1016/j.jneumeth.2012.09.025. Epub 2012 Oct 3. PMCID: PMC23041110.

Cai K, Xu HN, Singh A, Haris M, Reddy R, Li LZ.Characterizing prostate tumor mouse xenografts with CEST and MT-MRI and redox scanning. Adv Exp Med Biol. 2013;765:39-45.PMCID: PMC22879012.

Cai K, Haris M, Singh A, Li LZ, Reddy RBlood oxygen level dependent magnetization transfer (BOLDMT) effect. 2013;765:31-7. doi: 10.1007/978-1-4614-4989-8_5. PMCID: PMC22879011.

Cai K, Nanga RP, Lamprou L, Schinstine C, Elliott M, Hariharan H, Reddy R, Epperson CN. The impact of gabapentin administration on brain GABA and glutamate concentrations: a 7T ¹H-MRS study. 2012 Dec;37(13):2764-71. doi: 10.1038/npp.2012.142. Epub 2012 Aug 8. PMCID: PMC22871916.

Singh A, Cai K, Haris M, Hariharan H, Reddy R. On B1 inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T.  2013 Mar 1;69(3):818-24. doi: 10.1002/mrm.24290. Epub 2012 Apr 17. PMCID: PMC22511396.

Haris M, Nanga RP, Singh A, Cai K, Kogan F, Hariharan H, Reddy R.Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. NMR Biomed. 2012 Nov;25(11):1305-9. doi: 10.1002/nbm.2792. Epub 2012 Mar 20. PMCID: PMC22431193.

Cai K, Shore A, Singh A, Haris M, Hiraki T, Waghray P, Reddy D, Greenberg JH, Reddy RBlood oxygen level dependent angiography (BOLDangio) and its potential applications in cancer research. 2012 Oct;25(10):1125-32. doi: 10.1002/nbm.2780. Epub 2012 Feb 2. PMCID: PMC22302557.

Haris M, Nath K, Cai K, Singh A, Crescenzi R, Kogan F, Verma G, Reddy S, Hariharan H, Melhem ER, Reddy R.Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. NMR Biomed. 2012 Oct 9. doi: 10.1002/nbm.2875. [Epub ahead of print] PMCID: PMC3556355.

Haris M, Singh A, Cai K, Nath K, Crescenzi R, Kogan F, Hariharan H, Reddy R. MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. J Neurosci Methods. 2012 Oct 3;212(1):87-93. doi: 10.1016/j.jneumeth.2012.09.025. [Epub ahead of print] PMCID: PMC3508258.

Cai K, Nanga RP, Lamprou L, Schinstine C, Elliott M, Hariharan H, Reddy R, Epperson CN.The impact of gabapentin administration on brain GABA and glutamate concentrations: a 7T ¹H-MRS study. Neuropsychopharmacology. 2012 Aug 8. doi: 10.1038/npp.2012.142. [Epub ahead of print] PMCID: PMC22871916.

Singh A, Haris M, Cai K, Kassey VB, Kogan F, Reddy D, Hariharan H, Reddy R. Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3 T and 7 T. Magn Reson Med. 2012 Aug;68(2):588-94. PMCID: PMC22213239.

Kogan F, Singh A, Cai K, Haris M, Hariharan H, Reddy R. Investigation of chemical exchange at intermediate exchange rates using a combination of chemical exchange saturation transfer (CEST) and spin-locking methods (CESTrho). Magn. Reson. Med.2012 Jul;68(1):107-19. PMCID: PMC3564676, NIHMS332697.

Pilkinton DT, Hiraki T, Detre JA, Greenberg JH, Reddy R. Absolute cerebral blood flow quantification with pulsed arterial spin labeling during hyperoxia corrected with the simultaneous measurement of the longitudinal relaxation time of arterial blood. Magn. Reson. Med. 2012 Jun;67(6):1556-65. PMCID: PMC3523362.

Singh A, Cai K, Haris M, Hariharan H, Reddy R. On B1 inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T. Magn Reson Med. 2012 Apr 17. doi: 10.1002/mrm.24290. [Epub] PMCID: PMC22511396.

Cai K, Shore A, Singh A, Haris M, Hiraki T, Waghray P, Reddy D, Greenberg JH, and Reddy R. Blood oxygen level dependent angiography (BOLDangio) and its potential applications in cancer research, NMR in Biomed. February 2, 2012 [Epub]. PMCID: PMC3390450.

Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA, Reddy R. Magnetic resonance imaging of glutamate. Nature Medicine. 2012 Jan 22;18(2):302-6.  PCMID:PMC3274604.

Haris M, Cai K, Singh A, Hariharan H, Reddy R.In vivo mapping of brain myo-inositol. Neuroimage. February 1, 2011; 54(3):2079-85,PMCID: PMC3013615.

Pilkinton DT, Gaddam SR, Reddy R. Characterization of paramagnetic effects of molecular oxygen on blood oxygenation level-dependent-modulated hyperoxic contrast studies of the human brain. Magn. Reson. Med. 2011;66(3):794-801,PMCID: PMC21608026.

Mosher, TJ, Zhang, ZZ, Reddy R, Boudhar S, Milestone BN, Morrison WB, Kwoh CK, Eckstein F, Witschey W, Borthakur A, Olson C, ACRIN-PA 4001: Reproducibility of MR Image Biomarkers of Knee Articular Cartilage Damage in Osteoarthritis in a Multi-center trial, Radiology 258(3): 832-42, 2011. PMCID: PMC21212364.

Eric A. Mellon, Shashank Beesam R, Elliott M, Reddy R. Mapping of Cerebral Oxidative Metabolism with MRI. Proc. Natl. Acad. Sci. USA, 107(26):11787-11792, (2010). PMCID: PMC2900671.

Li LZ. Zhou R. Xu HN. Moon L. Zhong T. Kim EJ. Qiao H. Reddy R. Leeper D. Chance B. Glickson JD Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential, Proc. Natl. Acad. Sci. USA. 106(16): 6608-13(2009), PMCID: PMC2672511.

Mellon EA. Pilkinton DT. Clark CM. Elliott MA. Witschey WR 2nd. Borthakur A. Reddy R. Sodium MR imaging detection of mild Alzheimer disease: preliminary study. American Journal of Neuroradiology 30(5): 978-84 (2009), PMCID: PMC2866317.

Witschey WR. Borthakur A. Elliott MA. Fenty M. Sochor MA. Wang C. Reddy R. T1ρ-prepared balanced gradient echo for rapid 3D T1ρ MRI, J. Magn. Reson. Imaging, 28(3): 744 754, (2008), PMCID: PMC2593793.

Borthakur A, Corbo M, Trojanowski JQ, Lee Virginia MY, Reddy R. In vivo Measurement of Plaque Burden in a Mouse Model of Alzheimer’s Disease, J. Magn. Reson. Imaging 24,1011-7(2006), PMCID: PMC2859034.

Tailor DR, Baumgardner JE, Regatte RR, McLaughlin AC, Leigh JS, Reddy R. Proton MRI of Metabolically Produced H217O Using an Efficient 17O2 Delivery System, Neuroimage 22, 611(2004), PMCID: PMC15193589.

Wheaton AJ, Borthakur A, Corbi MT, Moonis G, Melhem E, Reddy R. T2rho contrast in MR images of the human brain. Magn Reson Med. 52, 1223-1227 (2004), PMCID: PMC15562499.

Tailor DR, Poptani H, Glickson JD, Leigh JS, Reddy R, High-Resolution Assessment of Blood Flow in Murine RIF-1 Tumors by Monitoring Uptake of H217O With Proton T1ρ-Weighted Imaging, Magn. Reson. Med., 49, 1-6 (2003), PMCID: PMC12509813.

Tailor DR, Roy A, Regatte RR, Charagundla SR, McLaughlin AC, Leigh JS, Reddy R. Indirect 17O-Magnetic Resonance Imaging of Cerebral Blood Flow in the Rat, Magn. Reson. Med. 49, 479-487 (2003), PMCID: PMC12594750.

Duvvuri U, Goldberg AD, Kranz JK, Hoang L, Reddy R, Wehrli FW, Wand AJ, Englander SW, Leigh JS. Water magnetic relaxation dispersion in biological systems: the contribution of proton exchange and implications for the noninvasive detection of cartilage degradation. Proc. Natl. Acad. Sci. USA, 2001;98 (22):12479-12484,PMCID: PMC60079.

Professional Memberships and Honors

National Merit Scholarship of Government of India
Member, International Society of Magnetic Resonance in Medicine
Member, Osteoarthritis Research Society International
Member, The New York Academy of Sciences
Member, Radiological Society of North America
Member, International Society of Oxygen Transport in Tissues
Member, Graduate group, Department of Biochemistry and Molecular Biophysics, University of Pennsylvania
Member and Chairman of graduate thesis committees, Department of Biochemistry and Molecular Biophysics, University of Pennsylvania
Member, Graduate group, Department of Bioengineering, University of Pennsylvania
Member, Executive Committee, Department of Radiology, University of Pennsylvania
Referee, Serving as referee for numerous journals in the field of biological NMR and MRI including Journal of Magnetic Resonance, NMR in Biomedicine, Journal of Magnetic Resonance Imaging, Magnetic Resonance in Medicine, Magnetic Resonance Imaging, Proceedings of National Academy of Sciences, USA, Arthritis and Rheumatism, Radiology, Hand Book of Alzheimer’s Disease, Transactions of IEEE
Member, Advisory committee, National High Magnetic Field Laboratory, Tallahassee, FL
Member, Advisory committee, MRI Center, University of Iowa, Iowa City, Iowa
Member, Organizing committee, NIH, NCRR/NIBIB P41 Principal Investigator meeting
Member, Grant Review Panel, U.S.-Israel Bi-national Science Foundation
Member, Ad hoc Grant Review Panel, National Science Foundation
Member, Serving on numerous NIH Ad hoc study sections
Member/Chair, Study sections, NIH Biomedical Technology Research Centers, P41 center site visiting teams
Member, Review panel, University Research Foundation, UPENN
Named to the Council of Distinguished Investigators of the Academy of Radiology Research
Appointed as the standing member for the Musculoskeletal Tissue Engineering (MTS) Study Section for the period June 2013-June 2017