Hari Hariharan, Ph.D.

Subgroup: Executive Committee, Faculty & Research Investigators

Associate Director (Tech Transfer), CMROI

Senior Research Investigator, Radiology

Contact Information

B1 Stellar-Chance Laboratories
422 Curie Blvd
Philadelphia, PA, USA 19104-6100

Tel:215-898-9357
Fax: 215-573-2113
Email: harih@mail.med.upenn.edu

Education

B.Sc. Chemistry, Madurai University, India

M.Sc. Chemistry, Indian Institute of Technology-Kanpur, Kanpur, India

Ph.D. Chemistry, Indian Institute of Technology-Kanpur, Kanpur, India

Recent Work

Research Interests

MRI and MRS Applications

CEST Imaging

MRS Post Processing SW development

Pulse Sequence Development

Professional Experience

1979-1981

Research Associate, Indian Institute of Technology, Kanpur

1981-1983

Post-doctoral Fellow, Department of Biophy/Biochem, University of Pennsylvania

1983-1984

Research Associate, Department of Biophy/BioChem, University of Pennsylvania.

1985-1990

Technical Director, MMRRCC, University of Pennsylvania.

1986-1990

Research Assistant Professor, Dept. of Biophy/BioChem, University of Pennsylvania.

1990-1991

MRS/MRI Applications Development Scientist, OTSUKA Electronics (USA) Inc, Fort Collins

1991-1995

MRI/MRS Applications Development Manager, OTSUKA Electronics (USA) Inc, Fort Collins

1995-1997

MRI/MRS Applications Development Manager, Elscint MR Inc, Fort Collins

1997-1999

General Manager(MFG), Elscint MR Inc, Fort Collins

1999-2009

MR Systems Engineer, GE Healthcare

2009-

Senior Research Investigator, Dept. of Radiology, University of Pennsylvania

Certifications

CITI Protection of Human Subjects Training

VPR

HIPPA Privacy Training

Selected Publications

In Vivo Metabolic Evaluation of Breast Tumor Mouse Xenografts for Predicting Aggressiveness Using the Hyperpolarized (13)C-NMR Technique. Xu HN, Kadlececk S, Pullinger B, Profka H, Cai K, Hariharan H, Rizi R, Li LZ. Adv Exp Med Biol. 2013;789:237-42. doi: 10.1007/978-1-4614-7411-1_32. PMCID: PMC3917450

Chemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications. Kogan F, Hariharan H, Reddy R.Curr Radiol Rep. 2013 Jun 1;1(2):102-114. PMID: 23730540

Imaging of glutamate in the spinal cord using GluCEST. Kogan F, Singh A, Debrosse C, Haris M, Cai K, Nanga RP, Elliott M, Hariharan H, Reddy R. Neuroimage. 2013 Aug 15;77:262-7. doi: 10.1016/j.neuroimage.2013.03.072. Epub 2013 Apr 9. PMID: 23583425

Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRI. Cai K, Singh A, Roalf DR, Nanga RP, Haris M, Hariharan H, Gur R, Reddy R. NMR Biomed. 2013 Apr 3. doi: 10.1002/nbm.2949. PMID: 23553932

Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer. Kogan F, Haris M, Singh A, Cai K, Debrosse C, Nanga RP, Hariharan H, Reddy R. Magn Reson Med. 2013 Feb 14. doi: 10.1002/mrm.24641. PMID: 23412909

Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. Haris M, Nath K, Cai K, Singh A, Crescenzi R, Kogan F, Verma G, Reddy S, Hariharan H, Melhem ER, Reddy R. NMR Biomed. 2012 Oct 9. doi: 10.1002/nbm.2875. PMID: 23045158

MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. Haris M, Singh A, Cai K, Nath K, Crescenzi R, Kogan F, Hariharan H, Reddy R.J Neurosci Methods. 2013 Jan 15;212(1):87-93. doi: 10.1016/j.jneumeth.2012.09.025. Epub 2012 Oct 3. PMID: 23041110

The impact of gabapentin administration on brain GABA and glutamate concentrations: a 7T ¹H-MRS study. Cai K, Nanga RP, Lamprou L, Schinstine C, Elliott M, Hariharan H, Reddy R, Epperson CN. Neuropsychopharmacology. 2012 Dec;37(13):2764-71. doi: 10.1038/npp.2012.142. Epub 2012 Aug 8. PMID: 22871916

On B(1) inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T. Singh A, Cai K, Haris M, Hariharan H, Reddy R.  Magn Reson Med. 2012 Apr 17. doi: 10.1002/mrm.24290. [Epub ahead of print]

Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. Haris M, Nanga RP, Singh A, Cai K, Kogan F, Hariharan H, Reddy R. NMR Biomed. 2012 Mar 20. doi: 10.1002/nbm.2792. [Epub ahead of print]

Magnetic resonance imaging of glutamate.  Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA, Reddy R. Nat Med. 2012 Jan 22;18(2):302-6.

Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3 T and 7 T. Singh A, Haris M, Cai K, Kassey VB, Kogan F, Reddy D, Hariharan H, Reddy R. Magn Reson Med. 2011 Dec 27. doi: 10.1002/mrm.23250. [Epub ahead of print]

Investigation of chemical exchange at intermediate exchange rates using a combination of chemical exchange saturation transfer (CEST) and spin-locking methods (CESTrho). Kogan F, Singh A, Cai K, Haris M, Hariharan H, Reddy R. Magn Reson Med. 2011 Oct 18. doi: 10.1002/mrm.23213. [Epub ahead of print]

In vivo mapping of brain myo-inositol. Haris M, Cai K, Singh A, Hariharan H, Reddy R. Neuroimage. 2011 Feb 1;54(3):2079-85. Epub 2010 Oct 14.

T2 and T2* quantification using optimal B1 image reconstruction for multicoil arrays. Graves MJ, Emmens D, Lejay H, Hariharan H, Polzin J, Lomas DJ. J Magn Reson Imaging. 2008 Jul;28(1):278-81.

T2 quantitation of articular cartilage at 1.5 T. Maier CF, Tan SG, Hariharan H, Potter HG.  J Magn Reson Imaging. 2003 Mar;17(3):358-64.