Subgroup: Executive Committee
Associate Director (Training and Dissemination), CMROI
Senior Research Investigator, Department of Radiology
B1 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Fax: (215) 573-2113
B.S. 1994, Angelo State University (Physics)
Ph.D. 2000, University of Pennsylvania (Biophysics)
M.B.A. 2014 (expected), The Wharton School, University of Pennsylvania
Develop novel spin-lock (or T1p) MRI applications
Perform quantitative studies via MR relaxometry
Implement multi-nuclear & multiple-quantum-filtered MRI capability on clinical scanners via: pulse sequence development
RF coil design and construction
The goal of our research is to develop non-invasive and non-destructive MRI techniques for the study of degenerative diseases such as Alzheimer's Disease and Degenerative Disc Disease. We facilitate timely clinical diagnoses by inventing and improving MRI pulse sequences and hardware. Our multi-nuclear and relaxometric techniques are routinely applied in model systems as well as in clinical research. We maintain active partnerships with faculty from Pathology, Neurology, Orthopedic Surgery and Rheumatology departments and train doctoral candidates from Biophysics and Bioengineering graduate programs at the University of Pennsylvania.
2010-present: Faculty, Bioengineering Graduate Group, University of Pennsylvania
2009-present: Associate Director, Center for Magnetic Resonance & Optical Imaging
2005-present: Faculty, Biochemistry & Molecular Biophysics Graduate Group, University of Pennsylvania
2004-present: Assistant Professor, Dept. of Radiology, University of Pennsylvania
2000-2004: Post-doctoral Researcher, Dept. of Radiology, University of Pennsylvania
1996-2000: Teaching Assistant, Dept. of Biophysics, University of Pennsylvania
1994-2000: Graduate Fellow, Dept. of Biophysics, University of Pennsylvania
Summer 1994: Research Assistant, Dept. of Radiology, University of Texas Medical School
Summer 1993: Intern, Dept. of Radiology, University of Texas Medical School
1992-1994: Lab Consultant, Microlab Facility, Angelo State University
Singh V, Raheja G, Borthakur A, Kumar A, Gill RK, Alakkam A, Malakooti J, Dudeja PK.Lactobacillus acidophilus upregulates intestinal NHE3 expression and function.2012 Dec 15;303(12):G1393-401. doi: 10.1152/ajpgi.00345.2012. Epub 2012 Oct 18. PMCID: PMC23086913
Mylliemngap BJ, Borthakur A, Velmurugan D, Bhattacharjee A. Insilico analysis and molecular docking of resuscitation promoting factor B (RpfB) protein of Mycobacterium tuberculosis. 2012;8(14):646-51. doi: 10.6026/97320630008646. Epub 2012 Jul 21. PMCID: PMC23055604
Borthakur A, Priyamvada S, Kumar A, Natarajan AA, Gill RK, Alrefai WA, Dudeja PK.A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1.2012 Nov 15;303(10):G1126-33. doi: 10.1152/ajpgi.00308.2012. Epub 2012 Sep 13. PMCID: PMC22982338
Borthakur A, Bhattacharyya S, Anbazhagan AN, Kumar A, Dudeja PK, Tobacman JK.Prolongation of carrageenan-induced inflammation in human colonic epithelial cells by activation of an NFκB-BCL10 loop. 2012 Aug;1822(8):1300-7. doi: 10.1016/j.bbadis.2012.05.001. Epub 2012 May 8. PMCID: PMC22579587.
Borthakur A, Maurer PM, Fenty M, Wang C, Berger R, Yoder J, Balderston RA, Elliott DM. T1ρ MRI and Discography Pressure as Novel Biomarkers for Disc Degeneration and Low Back Pain. Spine 2011; 36(25):1-7.
Borthakur A, Reddy R. Imaging Cartilage Physiology-A review. Topics in Magnetic Resonance 2010; 21(5):291–296.
Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VMY, Trojanowski JQ. Biomarkers for Early Detection of Alzheimer Pathology. Neurosignals 2008;16(1):11-18.
Borthakur A, Sochor M, Davatzikos C, Melhem ER, Trojanowski JQ, Clark CM. T1rho of Alzheimer's Disease. Neuroimage 2008;41:1199–1205.
Witschey WRT, Borthakur A, Elliott MA, Fenty M, Sochor M, Wang C, Reddy R. T1p-prepared balanced gradient echo for rapid 3D T1ρ MRI. Journal of Magnetic Resonance Imaging 2008; 28(3):744-754.
Auerbach JD, Johannessen W, Borthakur A, Wheaton AJ, Dolinskas CA, Balderston RA, Reddy R, Elliott DM. Quantitative in vivo Assessment of Human Lumbar Disc Degeneration Using T1p-weighted Magnetic Resonance Imaging. European Spine Journal 2006; 15:338-344.
Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R. In vivo Measurement of Plaque Burden in a Mouse Model of Alzheimer's Disease. Journal of Magnetic Resonance Imaging 2006; 24:1011-1017.
Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. Sodium and T1p MRI for Molecular and Diagnostic Imaging of Articular Cartilage (Review Article). NMR in Biomedicine 2006; 19: 781–821.