CMROI Seminar

WEDNESDAY, JULY 2, 2014

B1 STELLAR CHANCE LABS

12:00 NOON

“Longitudinal Metabolic Changes in a Mouse Model of Tauopathy”

Presented by Shelly Crescenzi

CMROI tech on display by Siemens at RSNA meeting

Researchers at the Center for Magnetic Resonance and Optical Imaging (CMROI) led by Prof. Ravinder Reddy have developed a MRI-based imaging technique called T1-rho MRI that can detect subtle early changes in cartilage physiology due to osteoarthritis that may provide improved diagnoses and clinical management of patients. This novel biomarker of cartilage pathology is sensitive to early biochemical changes in the extracellular matrix of cartilage and has the potential to non-invasively detect early pathological changes with the goal of aiding clinical decision-making as well as contributing to development and evaluation of potential disease modifying therapies. Siemens is developing a work-in-progress package with CMROI for deploying the pulse sequence and image reconstruction software for use on 3T MRI scanners. Siemens highlighted T1-rho MRI in their Magnetom Flash magazine at this year’s RSNA meeting.

For information on how to obtain the pulse sequence, please visit the T1-rho download page.

New Staff Position

Research Specialist Position available, please email resume to Susan Colleluori at colleluo@upenn.edu.

Duties

  • Perform Magnetic Resonance Imaging (MRI) experiments related to the research focus of the group – degenerative disc disease, Osteoarthritis, and Alzheimer’s Disease.
  • Act as liaison with active MRI research group and clinical departments e.g. Orthopaedic Surgery and Radiology.
  • Implement new MRI protocols focused on translational research.
  • Engage with and perform MRI scans on human research patients (may require early or late shift work).
  • Engage with and perform MRI scans on mice and guinea pigs (may require early or late shift work).
  • Routinely interface with regulatory bodies within the University (IRB, IACUC, CAMRIS)
  • Process data generated from MRI scans

Qualifications

  • Minimum of a Bachelor’s degree and 2 years of research experience or equivalent combination of education and research experience is required.
  • Bachelor’s degree required, Master’s degree preferred.
  • Proficient in Matlab for use in image analysis.
  • Comfortable with Linux and Windows environments.
  • Comfortable working with human research subjects as well as animals and animal specimens.
  • Able to write scientific publications.
  • Able to work independently and also as a part of a small team.