Penn Links



Biomedical Technology Research Resources

Biomedical Technology Research Resources (BTRRs) create critical, often unique technology and methods at the forefront of their respective fields, and apply them to a broad range of basic, translational, and clinical research. This is accomplished through a synergistic interaction of technical and biomedical expertise, both within the resources and through intensive collaborations with other leading laboratories.

BTRRs serve a unique purpose in the broad context of NIH-funded research. They represent a critical mass of technological and intellectual resources with a strong focus on service and training for outside investigators, as well as dissemination of technologies, methods, and software. Their goal is to promote the widespread and routine application of the cutting-edge technologies they develop across the full spectrum from bench to bedside.

  1. Multidisciplinary & collaborative, a catalyst for integrating diverse research efforts
  2. Often one-of-a-kind, scarce, or expensive
  3. State-of-the-art resources for NIH-funded researchers
    • Technological Infrastructure
    • Experimental and Computational Resources
    • Expertise

Imaging Technology

Some BTRRs focus on pursuing cutting-edge development and improvement of technologies and methods for imaging and spectroscopy to study areas such as organ structure and function, perfusion, oxygen extraction, and metabolism for the diagnosis, staging, treatment evaluation and investigating diseases and abnormalities. This requires expertise and integration of many areas of science: physics, chemistry, electrical and computational engineering, mathematics, biology, and medicine.

The imaging centers are located in major research intensive medical centers providing a supportive environment for interdisciplinary research and exceptional opportunities to identify proper collaborations to drive the technology development. This proximity contributes as well to the reduction in translation barriers to clinical applications.

Resource Centers

BioCurrents Research Center P.I.: Peter J. S. Smith, Ph.D. tools to follow the dynamic properties of living cells
Center for Advanced Magnetic Resonance Technology at Stanford P.I.: Gary H. Glover, Ph.D. development of magnetic MRI techniques in humans and animals
Center for Functional Imaging Technologies P.I.: Bruce R. Rosen, M.D., Ph.D. development of neuroimaging techniques in humans
Integrated Center for In Vivo Microscopy P.I.: G. Allan Johnson, Ph.D. developing techniques for very high resolution imaging of small animal models
National Center for Microscopy and Imaging Research P.I.: Mark H. Ellisman, Ph.D. tools and techniques for electron microscopy at the cellular level
National Center for X-Ray Tomography P.I.: Carolyn Larabell, Ph.D. x-ray microscopy at the cellular level
National Resource Center for Image-Guided Therapy P.I.: Ferenc A. Jolesz, M.D. image guided therapy
NMR Imaging and Localized Spectroscopy P.I.: Kamil Ugurbil, Ph.D. MRI using ultrahigh magnetic fields
Resource for Magnetic Resonance and Optical Imaging P.I.: Ravinder Reddy, Ph.D. high performance computing
Resource for Quantitative Functional MRI P.I.: Peter C. M. van Zijl, Ph.D. development of MRI techniques in humans
Southwestern NMR Center for In Vivo Metabolism P.I.: Craig R. Malloy, M.D. imaging techniques to understand metabolic changes in humans

Optical and Laser Technology

The four optical/spectroscopic BTRRs develop optical instrumentation and methodologies to probe the structure and dynamics of biologically relevant samples ranging in complexity from single molecules to cells and tissues. Innovative technologies are applied to elucidate fundamental biological mechanisms and to diagnose and investigate molecular and cellular abnormalities, both in vitro and in vivo.

Development of cutting-edge technologies requires integration of multiple disciplines, including physics, chemistry, engineering and biological sciences. The centers are situated in major research institutions that provide a multidisciplinary environment with a wide range of expertise and resources. This milieu promotes the collaborative ventures with laboratory scientists and clinicians that drive technology development and translation to the clinic and marketplace.

Resource Centers

Laboratory for Fluorescence Dynamics P.I.: Enrico Gratton, Ph.D fluorescence spectroscopy
Laser Biomedical Research Center P.I.: Michael S. Feld, Ph.D. laser-based spectroscopic techniques for medical applications
Laser Microbeam and Medical Program P.I.: Bruce J. Tromberg, Ph.D. interactions of light with tissue
Ultrafast Optical Processes Laboratory P.I.: Robin M. Hochstrasser, Ph.D. laser technologies to elucidate biological structure and dynamics